Description

Crystagen – Research-Grade Immune System Tripeptide

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Cocer Peptides is proud to offer Crystagen, a high-purity research-grade tripeptide bioregulator with the amino acid sequence Glu-Asp-Pro (EDP).

With a molecular formula of C₁₄H₂₁N₃O₈ and a molecular weight of 359.335 g/mol, this short peptide represents a significant tool for researchers investigating immune system function and lymphocyte regulation.

This compound belongs to the class of peptide bioregulators developed within the framework of Russian peptide research, specifically designed to modulate immune system activity through cellular signalling mechanisms.

⚠️ Important Notice: This product is supplied for laboratory research use only. It is not intended for human or veterinary consumption and must not be used in clinical or therapeutic applications.

As a research peptide, this compound provides scientists with a reliable tool for investigating immune cell proliferation, T lymphocyte activation, and the molecular mechanisms underlying immune system regulation.

The compound is of particular interest to researchers studying thymus function, lymphocyte differentiation, and the effects of peptide bioregulators on immune homeostasis.

The National Institutes of Health maintains extensive databases on peptide research, and investigations into this compound continue to expand our understanding of immune system modulation.

Research published in peer-reviewed journals and documented in the PubMed database has explored the biochemical properties and potential research applications of this peptide.

The Google Scholar database provides access to thousands of citations on peptide bioregulation and immune research.

Meanwhile, ScienceDirect and ResearchGate offer additional resources for researchers exploring immune-modulating peptides.

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What Is Crystagen?

This compound is a synthetic tripeptide bioregulator consisting of three amino acids: glutamic acid, aspartic acid, and proline (Glu-Asp-Pro).

It was developed through systematic exploration of thymus function and its secretory substances, leading to its deliberate synthesis as an immune-modulating agent.

Bioregulatory peptides are short amino acid sequences that influence physiological processes through cellular signalling mechanisms.

Structure and Composition:

Research has demonstrated that this peptide exhibits multi-level, multi-target biological regulatory capabilities, with its core efficacy lying in the precise modulation of immune system function.

The peptide is manufactured as a lyophilised solid, a drying process that preserves structural integrity and ensures stability during storage.

This form allows researchers to reconstitute the peptide at desired concentrations for specific assay requirements.

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Chemical and Structural Properties

Molecular Characteristics

The tripeptide sequence Glu-Asp-Pro (EDP) provides this compound with its specific biological activity.

Research published in Advances in Gerontology has shown that short peptides such as this compound possess age-associated immunoprotecting activity.

The peptide’s molecular weight of 359.335 g/mol positions it within the class of small peptides capable of efficient cellular interaction and signalling.

These structural properties—accessible via the NIH chemical database—enable this compound to function as a bio-regulatory peptide that mimics endogenous immune signalling molecules.

Purity and Quality Standards

This compound is manufactured to meet research-grade specifications with a guaranteed purity of ≥98% verified by High-Performance Liquid Chromatography (HPLC).

This level of purity is essential for research applications where contaminant interference could compromise experimental validity.

Independent batch testing is conducted to verify:

• Peptide identity and sequence confirmation

• Purity verification via HPLC

• Residual solvent analysis

• Endotoxin testing (where applicable)

Researchers can access the Certificate of Analysis (COA) for each batch, providing full transparency on product quality and testing parameters.

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Research Applications

T Lymphocyte Regulation

The primary research interest in this compound centres on T lymphocyte regulation and immune cell biology.

Studies have demonstrated that this peptide acts directly on cellular immune responses, promoting faster and more effective activation of T cells.

It specifically targets helper Th cells and cytotoxic T lymphocytes, stimulating their proliferation, activation, and subsequent secretion of effector molecules.

Research has also shown that this compound promotes the increased expression of CD3, an immature T cell marker, indicating its role in T cell development and maturation.

These findings suggest this peptide may be a valuable tool for investigating T cell biology and immune activation pathways.

Natural Killer Cell Proliferation

This compound has demonstrated the ability to induce proliferation of Natural Killer (NK) cells.

NK cells play a critical role in the body’s innate immune response against viral infections and tumour cells.

The peptide’s capacity to stimulate NK cell proliferation makes it a valuable research tool for investigating innate immunity and cancer immunology.

Studies accessible via ResearchGate have documented its effects on NK cell populations.

B Cell Activation and Humoral Immunity

Research indicates that this compound modulates B cell activation and humoral immunity.

It influences B-cell related activation, synergistically completing the immune response alongside T cell modulation.

Studies have confirmed that this peptide activates B-cells of the immune system.

This dual action on both cellular and humoral immunity makes this compound a comprehensive tool for investigating the full spectrum of immune function.

Immune System Homeostasis

This compound has been studied for its role in maintaining immune system homeostasis.

Research has demonstrated that the peptide restores proper proportions of different immune cell subsets.

This re-establishment of immune surveillance, active defence, and clearance functions represents a key research application for the peptide.

Studies published in Advances in Gerontology and indexed on ScienceDirect have explored its age-associated immunoprotecting activity.

The peptide has been shown to restore cell content in the main subpopulations of the immune system upon high exercise stress.

Cell Protection and Homeostatic Maintenance

This compound exhibits cytoprotective effects specifically on immune cells.

Research indicates that the peptide mitigates oxidative stress damage to immune cells through upregulation of various intracellular antioxidants, with glutathione being a prime example.

Simultaneously, it inhibits the mitochondrial apoptosis pathway through regulated expression of Bcl-2 family proteins.

This reduced apoptosis leads to longer survival times and subsequent functional endurance of immune cells.

Anti-Inflammatory Research

Some research has reported a direct anti-inflammatory effect of this compound.

The peptide reduces various forms of immune stress damage the body incurs during inflammatory responses.

This property makes this compound a potentially valuable tool for investigating inflammatory conditions and immune-mediated tissue damage.

Cancer Adjuvant Research

This compound has been investigated in the context of cancer adjuvant therapy research.

The peptide’s ability to enhance immune surveillance and anti-tumour immune responses positions it as a research tool for oncology studies.

Research available through Google Scholar has explored the potential applications of immune-modulating peptides in cancer research.

Age-Related Immunosenescence Research

This compound is a valuable tool for investigating age-related changes in immune function.

Research published in Advances in Gerontology has demonstrated that short peptides such as this compound possess age-associated immunoprotecting activity.

Studies have shown that the peptide can restore immune function in aging models, making it a useful compound for investigating immunosenescence.

Spleen Function Research

This compound has been studied for its effects on spleen function and cellular renewal.

Research by Chervyakova et al., published in Advances in Gerontology and indexed on PubMed, investigated age-related molecular aspects of immunomodulating activity of peptides in the spleen.

The study demonstrated that this peptide exhibits age-associated immunoprotecting effects in splenic tissue.

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Technical Specifications

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Reconstitution and Handling Protocol

Recommended Storage Conditions

This compound is supplied as a lyophilised solid and should be stored at 2–8°C to maintain stability and potency.

Proper temperature control prevents degradation and preserves the peptide’s structural integrity.

• Short-term storage: 2–8°C (refrigeration)

• Long-term storage: -20°C or below (freezer)

• Protect from light: Store in original packaging or dark conditions

• Do not freeze: After reconstitution, avoid repeated freeze-thaw cycles

Reconstitution Guidelines

For best results in a research setting, allow both the peptide and chosen solvent to reach ambient laboratory temperature before reconstitution.

This helps maintain structural integrity during dissolution.

Standard reconstitution protocol:

1. Bring lyophilised peptide and solvent to room temperature

2. Add the appropriate volume of sterile solvent (water for injection, PBS, or bacteriostatic water)

3. Gently swirl—do not vortex or shake vigorously

4. Allow to fully dissolve before use

5. Use within the recommended timeframe

Dissolved solutions should be aliquoted and stored at -20°C to avoid repeated freeze-thaw cycles, and are best used fresh after preparation.

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Quality Assurance and Testing

Cocer Peptides is committed to providing research-grade compounds that meet the highest standards of quality and consistency.

Each batch undergoes rigorous testing to verify:

• Identity confirmation: Mass spectrometry verification

• Purity analysis: HPLC with ≥98% purity threshold

• Content uniformity: Consistency across vials

• Residual solvent analysis: Within acceptable limits

Independent third-party testing is conducted to ensure unbiased verification.

Researchers can view the Certificate of Analysis for their specific batch directly on our site, providing full transparency and traceability.

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Frequently Asked Questions (FAQ)

What is Crystagen?

This compound is a synthetic tripeptide bioregulator composed of glutamic acid, aspartic acid, and proline (Glu-Asp-Pro).

It is a research peptide designed to modulate immune system function through cellular signalling mechanisms.

Comprehensive research on immune-modulating peptides is available through PubMed and Google Scholar.

What is the purity of Crystagen?

This compound is guaranteed to have a purity of ≥98% verified by HPLC testing.

Each batch is independently tested to ensure quality and consistency.

How should Crystagen be stored?

This compound should be stored at 2–8°C as a lyophilised solid.

After reconstitution, it should be refrigerated and used within the recommended timeframe to maintain stability.

What research applications is Crystagen used for?

This compound is used in research exploring T lymphocyte regulation, NK cell proliferation, B cell activation, immune system homeostasis, cell protection, anti-inflammatory mechanisms, cancer adjuvant research, and age-related immunosenescence.

For a comprehensive overview of peptide research applications, researchers are encouraged to explore the PubMed database.

ScienceDirect and ResearchGate offer additional resources for researchers exploring immune-modulating peptides.

How should I reconstitute Crystagen?

Allow both the peptide and solvent to reach room temperature before reconstitution.

Add the appropriate volume of sterile solvent and gently swirl to dissolve.

Do not vortex or shake vigorously.

Is Crystagen approved for human use?

No. This compound is strictly for laboratory research use only and is not approved for human or veterinary use as a research product.

This product must not be used in clinical or therapeutic applications.

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Conclusion

Crystagen (Glu-Asp-Pro) represents a powerful research tool for scientists investigating immune system function, T lymphocyte regulation, and peptide-mediated immune modulation.

With a molecular weight of 359.335 g/mol and guaranteed purity of ≥98%, this tripeptide bioregulator offers the consistency and reliability required for reproducible research outcomes.

The peptide’s demonstrated effects in T cell activation, NK cell proliferation, B cell modulation, immune homeostasis maintenance, and cytoprotection make it a versatile tool for immunological research.

Research published in peer-reviewed journals and documented in the PubMed database has explored the biochemical properties and potential research applications of this peptide.

The Google Scholar database provides access to thousands of citations on peptide bioregulation and immune research.

Meanwhile, ScienceDirect and ResearchGate offer additional resources for researchers exploring immune-modulating peptides.

As with all research peptides, this compound is intended for laboratory use only and should be handled according to established protocols for peptide-based research.

Cocer Peptides is proud to provide UK researchers with access to high-quality, independently tested research compounds.

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Related Research Products

• Bioregulator Peptides – View our complete bioregulator collection

• Certificate of Analysis – Access batch-specific COA data

• Research Peptides – Explore our full peptide catalogue

• Reconstitution Guide – Comprehensive handling protocols

• Contact Us – For research support and enquiries

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Disclaimer: This product is supplied for laboratory research use only. It is not intended for human or veterinary use and must not be used in any medical, therapeutic, or clinical applications. The information provided is for educational and research purposes only. Always follow standard laboratory safety protocols when handling research compounds.