Description

Buy Vesilute 20mg – High-Purity Research Peptide

Product Overview

Vesilute is a synthetic dipeptide bioregulator with the amino acid sequence Glu-Asp (glutamic acid-aspartic acid), belonging to the Khavinson class of ultrashort peptide bioregulators. These two- to four-residue peptides are studied for their roles in gene expression regulation, cellular communication, and tissue-specific homeostasis. If you are looking to buy Vesilute in the UK, Cocer Peptides supplies high-purity lyophilised powder with verified ≥99% purity.

Vesilute is a distinct entity from Vesugen, which is the tripeptide Lys-Glu-Asp. The two carry different sequences, molecular formulas, and registry numbers, and they are not interchangeable in a research protocol. The compound carries CAS number 3918-84-1 and PubChem CID 99716, with the molecular formula C₉H₁₄N₂O₇ and a molecular weight of 262.22 g/mol.

Researchers who buy Vesilute from Cocer Peptides receive full analytical documentation with every order. If you need to buy Vesilute for laboratory applications, this product is supplied strictly for research use only and is not intended for human or veterinary use, as outlined by the FDA.

Product Specifications

Mechanism of Action

Peptide Transport and Cellular Uptake

Ultrashort peptides of two to four residues have been examined for their ability to cross cell and nuclear membranes. Molecular modelling work has named the Glu-Asp dipeptide directly: in a docking study of 26 biologically active ultrashort peptides against the LAT1, LAT2, and PEPT1 transporters, ED was among the sequences with the highest binding scores, alongside DS, DR, EDR, and EDG. The authors grouped these together as peptides carrying a negatively charged Asp or Glu residue at the N-terminus, and proposed transporter-mediated uptake as a route into the cell for peptides of this class.

Gene Expression Regulation

A systematic review catalogued peptide interactions with promoter regions across plant, microbial, insect, avian, and rodent model systems, framing those interactions as a route to altered gene expression in culture. The peptide bond itself appears to matter in these models: a comparison of the Lys-Glu dipeptide against a mixture of its two free amino acids in organotypic spleen culture found opposite directions of effect on culture growth, and docking calculations placed the dipeptide in the DNA minor groove with a higher interaction energy than either amino acid alone.

Cell Signalling Readouts

Cell-line work has extended the picture to signalling readouts. In the THP-1 monocytic cell line, five Khavinson peptides were reported to raise tyrosine phosphorylation of mitogen-activated cytoplasmic kinases, and to change TNF and IL-6 expression in cultures stimulated with bacterial lipopolysaccharide.

Research Applications

Peptide Transport and Uptake Studies

Vesilute is studied as a reference compound for investigating transporter-mediated uptake of ultrashort peptides. The Glu-Asp sequence’s high binding scores against LAT1, LAT2, and PEPT1 transporters make it valuable for research into cellular entry mechanisms of small peptides, as documented in the NIH PubMed database.

Gene Expression and Molecular Modelling

Researchers use Vesilute in promoter-binding and expression assays in cultured cell lines, as well as in molecular docking studies examining peptide-DNA and peptide-histone interactions. The compound serves as a tool for understanding how dipeptides influence chromatin structure and gene transcription.

Comparative Peptide Chemistry

Vesilute is studied alongside free amino acid mixtures to investigate the specific role of the peptide bond in biological activity. Culture models comparing intact dipeptides against free amino acid mixtures provide insight into structure-activity relationships of ultrashort peptides, as detailed in Springer’s Amino Acids journal.

Analytical Method Development

A UPLC-MS/MS panel quantified 33 dipeptides across paired biofluid samples, detecting 18 in cerebrospinal fluid and 20 in plasma. That work establishes dipeptides as measurable analytes and gives method-development labs a published quantification framework to work from, with Vesilute serving as a reference standard. Additional analytical standards are available via the National Institute of Standards and Technology.

Quality and Purity

Each batch of Cocer Peptides Vesilute undergoes rigorous quality control:

• ≥99% purity verified by HPLC

• Correct molecular weight confirmed by mass spectrometry

• Third-party tested with Certificates of Analysis (COA) available

• Sterility and mycoplasma tested

For researchers seeking to buy Vesilute from a UK supplier, verifying COA documentation is essential. When you buy Vesilute from Cocer Peptides, you receive full batch traceability and transparency. Guidance on peptide quality assessment is available from the European Medicines Agency.

Frequently Asked Questions

What is Vesilute?

Vesilute is a synthetic dipeptide built from L-glutamic acid joined to L-aspartic acid, catalogued under CAS number 3918-84-1 and PubChem CID 99716. It belongs to the Khavinson family of ultrashort peptide bioregulators studied in cell-culture and molecular-modeling work.

What is the amino acid sequence of Vesilute?

Vesilute has the sequence Glu-Asp, written H-Glu-Asp-OH and abbreviated ED, giving it two residues and a molecular weight of 262.22 g/mol.

Is Vesilute the same as Vesugen?

No. Vesilute is the dipeptide Glu-Asp, while Vesugen is the tripeptide Lys-Glu-Asp, so the two differ in sequence, molecular formula, and CAS registry number.

Where can I buy Vesilute in the UK?

If you need to buy Vesilute in the UK for laboratory research, Cocer Peptides is a trusted supplier offering ≥99% purity with full COA documentation. You can buy Vesilute directly from our product page with fast, discreet UK shipping.

What purity level can I expect?

Our Vesilute is provided at ≥99% purity, verified by HPLC with third-party testing.

How should Vesilute be stored?

Store lyophilised powder at -20°C for long-term stability, protected from light. Reconstituted material should be stored at 2–8°C and used promptly following standard laboratory protocols.

Is this product suitable for human use?

No. This product is supplied for research purposes only and is not intended for human or veterinary use.

Conclusion

Vesilute represents a valuable research tool for investigating peptide transport mechanisms, gene expression regulation, and cellular signalling pathways. With its high-purity formulation and comprehensive quality documentation, this 20mg vial enables researchers to study ultrashort peptide biology in controlled laboratory settings. For scientists seeking to buy Vesilute for laboratory applications, Cocer Peptides provides a reliable UK-based source with full analytical transparency. When you buy Vesilute from Cocer Peptides, you are investing in verified purity and reproducible research outcomes. Whether you need a single vial or bulk quantities, you can buy Vesilute with confidence from Cocer Peptides.

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Order premium Vesilute 20mg for your laboratory today. Contact our team for COA requests or technical inquiries.

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