Description

Buy Semax 10mg – High-Purity Research Peptide

Product Overview

Semax is a synthetic heptapeptide developed for advanced research into neurotrophic signalling, cognitive function, and neuroprotective mechanisms. With the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro, Semax is an analogue of the adrenocorticotropic hormone (ACTH) fragment 4-7, extended with a C-terminal Pro-Gly-Pro sequence that enhances metabolic stability . This structural modification allows the peptide to resist rapid enzymatic degradation while retaining the neurotrophic properties of the parent ACTH fragment .

If you are looking to buy Semax in the UK, Cocer Peptides supplies high-purity lyophilised powder with verified ≥99% purity. Researchers who buy Semax from Cocer Peptides receive full analytical documentation with every order. Semax has been extensively studied in models of neuroprotection, synaptic plasticity, and stress-response biology, making it a valuable tool for neuroscience and peptide signalling research .

Important Notice: This product is supplied for research purposes only and is not intended for human or veterinary use. The FDA has stated there is insufficient clinical information to characterize the safety profile of semax, and no pharmacokinetic studies in humans were identified .

Product Specifications

Mechanism of Action

Neurotrophic Factor Upregulation

The most mechanistically robust finding in Semax research is its effect on neurotrophins. Studies have demonstrated that Semax upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in the hippocampus and cortex . Research by Dolotov and colleagues published in Brain Research showed that a single intranasal application of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels accompanying a 1.6-fold increase of trkB tyrosine phosphorylation, and a 3-fold and 2-fold increase of exon III BDNF and trkB mRNA levels in the rat hippocampus . This demonstrated engagement of the BDNF-TrkB signalling axis.

Neurotransmitter Modulation

Semax influences multiple neurotransmitter systems including dopaminergic, serotonergic, and cholinergic pathways. Research published in Neurochemical Research demonstrated that Semax activates dopaminergic and serotoninergic brain systems in rodents, with the tissue content of 5-hydroxyindoleacetic acid significantly increased in the striatum . Through its impact on dopamine and serotonin concentrations, Semax regulates mood stability, cognitive functions, and attention processes in experimental models.

Neuroprotective Mechanisms

Semax functions as a neuroprotectant through multiple pathways. Research published in ACS Chemical Neuroscience demonstrated that Semax inhibits copper-induced Aβ aggregation and prevents the formation of Aβ:Cu²⁺ complexes, suggesting potential relevance for Alzheimer’s disease research . Studies have also shown that Semax promotes functional recovery after spinal cord injury by targeting μ-opioid receptors and regulating USP18-mediated deubiquitination . Additional research in Cell Molecular Neurobiology showed that Semax and its C-terminal Pro-Gly-Pro fragment activate neurotrophin and receptor transcription after cerebral ischemia .

Research Applications

BDNF and Neurotrophic Signalling Studies

Semax is extensively used as a molecular probe for studying neuropeptide-mediated signalling pathways and neurotrophic factor regulation. Researchers investigate its effects on BDNF and NGF expression, synaptic plasticity, and neuronal survival mechanisms . The peptide’s ability to influence neurotrophic activity makes it particularly valuable in experimental setups examining brain plasticity and neural adaptation.

Cognitive Function and Memory Research

Semax has been studied in models of memory formation, learning, and attention. Preclinical research indicates potential effects on cognitive markers during periods of high-intensity mental load . A placebo-controlled study using resting-state functional MRI in 24 healthy volunteers found greater volume of the rostral medial-frontal-cortex subcomponent of the default mode network in the Semax group compared to controls, though the single-dose design and small sample size limit the strength of this finding .

Cerebrovascular and Ischemic Research

The strongest clinical evidence for Semax comes from Russian stroke trials. A 2018 study by Gusev and colleagues enrolled 110 post-stroke patients receiving 6,000 mcg/day intranasally and reported improvements on the Barthel index and MRC motor scale alongside elevated plasma BDNF, though the trial was non-randomised and not placebo-controlled . A meta-analysis of Russian literature found that Semax 1% intranasal administration in the acute period of stroke led to neurological impairment decrease and mobility increase . Earlier clinical trials demonstrated that including Semax in combined intensive therapy of acute ischemic stroke influenced the rate of restoration of damaged neurological functions, with the most effective daily doses being 12 mg for moderate strokes and 18 mg for severe strokes .

Neurodegenerative Disease Research

Recent research has investigated Semax in the context of Alzheimer’s disease. The peptide’s ability to inhibit copper-catalysed oxidation of amyloid-beta and decrease associated ROS production suggests potential relevance for neurodegenerative disorder research . Studies have also explored Semax effects on cognitive processes and neurotransmitter systems in various experimental models. A 2021 study published in Neuropeptides demonstrated that Semax attenuated behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats .

Quality and Purity

Each batch of Cocer Peptides Semax undergoes rigorous quality control:

• ≥99% purity verified by HPLC

• Correct molecular weight confirmed by mass spectrometry

• Third-party tested with Certificates of Analysis (COA) available

• Sterility and mycoplasma tested

For researchers seeking to buy Semax from a UK supplier, verifying COA documentation is essential. When you buy Semax from Cocer Peptides, you receive full batch traceability and transparency. The FDA has noted concerns about potential immunogenicity of semax-related bulk drug substances due to the potential for aggregation and peptide-related impurities .

Frequently Asked Questions

What is Semax?

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is an analogue of the ACTH(4-7) fragment, extended with a C-terminal Pro-Gly-Pro sequence . It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and is studied for neurotrophic and neuroprotective properties in laboratory research settings .

What is Semax used for in research?

Semax is studied in BDNF and neurotrophic-factor research, cerebrovascular research models, cognitive research assays, dopaminergic-system signalling, and melanocortin-receptor binding studies . These are areas of published research interest only.

Is Semax approved for human use?

No. Semax is not approved by the FDA, European Medicines Agency, or UK regulators for any therapeutic indication. International neurology guidelines do not list it . The FDA has stated there is insufficient clinical information to characterize the safety profile of semax .

Where can I buy Semax in the UK?

If you need to buy Semax in the UK for laboratory research, Cocer Peptides is a trusted supplier offering ≥99% purity with full COA documentation. You can buy Semax directly from our product page with fast, discreet UK shipping.

What purity level can I expect?

Our Semax is provided at ≥99% purity, verified by HPLC with third-party testing.

How should Semax be stored?

Store lyophilised powder at -20°C for long-term stability. Reconstituted material should be stored at 2–8°C and used promptly following standard laboratory protocols.

Is this product suitable for human use?

No. This product is supplied for research purposes only and is not intended for human or veterinary use.

Conclusion

Semax represents a valuable research tool for investigating neurotrophic signalling, neuroprotective mechanisms, and cognitive function pathways. With its high-purity formulation and comprehensive quality documentation, this 10mg vial enables researchers to study BDNF upregulation, neurotransmitter modulation, and the peptide’s diverse neurological effects . For scientists seeking to buy Semax for laboratory applications, Cocer Peptides provides a reliable UK-based source with full analytical transparency. When you buy Semax from Cocer Peptides, you are investing in verified purity and reproducible research outcomes.

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Order premium Semax 10mg for your laboratory today. Contact our team for COA requests or technical inquiries.

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