Description

Top AOD 9604 Peptide – UK Research Grade

Product Overview

If you are looking for AOD 9604 peptide for laboratory research in the UK, Cocer Peptides supplies a high-purity, research-grade version of this synthetic growth hormone fragment. AOD 9604 is a C-terminal fragment of human growth hormone (residues 177-191) with an added N-terminal tyrosine, engineered specifically to study lipolytic signalling pathways without the growth-promoting effects associated with full-length growth hormone. Its molecular structure distinguishes it from complete growth hormone because it does not bind the growth hormone receptor or stimulate IGF-1 production in vitro studies, as documented in Frontiers in Endocrinology.

The development history dates back to the late 1990s, when Metabolic Pharmaceuticals developed it as a potential oral anti-obesity drug. That research ultimately failed to show statistically significant weight loss compared with placebo, and development was discontinued. The compound’s history is catalogued in the NIH PubChem database. Despite this clinical history, AOD 9604 continues to serve as a research tool in laboratory settings for studying the lipolytic effects of growth hormone fragments on lipid metabolism.

Researchers seeking this peptide typically need research-grade material with complete analytical documentation. Every batch from Cocer Peptides includes a Certificate of Analysis (COA) showing HPLC purity and mass spectrometry confirmation.

Important Notice: This product is supplied for laboratory research use only and is not intended for human or veterinary use. AOD 9604 is not authorised by the Medicines and Healthcare products Regulatory Agency (MHRA) as a medicine and has not been approved by the FDA for any indication. Under World Anti-Doping Agency (WADA) rules, it is classified as a prohibited substance under category S2.2.

Product Specifications

Mechanism of Action

Lipolytic Signalling Pathway

AOD 9604 peptide is studied for its effects on lipolytic (fat-breaking) signalling pathways. Unlike full-length growth hormone, it is structurally engineered to retain lipolytic effects on adipose tissue while avoiding growth hormone receptor-mediated proliferative activity. Chronic subcutaneous administration in preclinical models has been shown to increase fat oxidation and lipolysis markers, and to attenuate weight gain in obese mice, according to research indexed in the NIH PubMed database.

No Growth Hormone Receptor Binding

The defining characteristic of this compound is its reported lack of growth hormone receptor binding. According to research published in Frontiers in Endocrinology, it showed no growth hormone receptor binding or growth hormone receptor-mediated proliferative activity in vitro studies. It also did not affect serum IGF-1 levels in clinical studies, unlike full-length human growth hormone. These findings are further supported by data in the NIH PMC database.

Metabolic Profile

Human studies indicate that AOD 9604 peptide did not negatively affect carbohydrate metabolism in oral glucose tolerance tests. In an intravenous dosing study involving 15 male subjects, doses ranged from 25 to 400 mg/kg, with adverse events distributed evenly between treatment and placebo. The study noted that the adverse event profile was similar across all treatments, as reported in ScienceDirect.

Research Applications

Obesity and Weight Regulation Research

As an oral anti-obesity drug candidate, AOD 9604 peptide was tested in a 24-week study involving 534 subjects, of whom 502 were randomised. The study failed to demonstrate a significant benefit on the primary weight loss endpoint. The study authors noted that the conclusion regarding lack of clinical efficacy for obesity was based primarily on sponsor-reported Phase 2 programme results, published via The BMJ. This historical data provides important context for researchers using this peptide as a tool compound.

Joint and Cartilage Research

Early research explored this peptide in the context of osteoarthritis and joint repair. While claims regarding joint repair are currently based mainly on animal studies (for example, intra-articular administration ± hyaluronic acid improving cartilage-related outcomes in rabbit OA models), convincing human clinical trial evidence in these indications is lacking. Cartilage research remains at the preclinical stage, as documented in Nature.

Metabolic Research

AOD 9604 peptide has been studied for its effects on metabolism without activating the growth hormone receptor. Preclinical studies examined its effects on lipid metabolism in obese mice and β3-AR knockout mice. These foundational studies provide a reference for researchers purchasing it for metabolic pathway research, with relevant data indexed in the NIH PubMed database.

Cell Signalling Research

This peptide allows researchers to study growth hormone fragment signalling pathways without the confounding effects of full-length growth hormone. Its role in lipolytic and anti-adipogenic signalling can be examined independently. For laboratories studying growth hormone fragment-specific effects, it provides a structurally well-defined tool compound, with related receptor pharmacology documented by Nature Reviews Endocrinology.

Quality and Purity

Every batch of AOD 9604 peptide from Cocer Peptides undergoes rigorous quality control:

• ≥99% purity verified by HPLC

• Molecular weight confirmed by mass spectrometry

• Batch number matching the vial label

• Certificate of Analysis (COA) available on request

According to MHRA guidance, selling or supplying unlicensed medicinal products in the UK is unlawful, and consumers should verify the legality of their purchase sources. The UK Government has taken enforcement action against online sellers of unlicensed peptide products and advises consumers to buy medicines only from regulated UK pharmacies.

Frequently Asked Questions

What is AOD 9604 peptide?

AOD 9604 peptide is a synthetic fragment of human growth hormone (residues 177-191) with an added N-terminal tyrosine. It was developed to study lipolytic effects while avoiding growth hormone receptor activation, as described in Frontiers in Endocrinology.

Is AOD 9604 the same as growth hormone?

No. It is a 15-amino-acid fragment of growth hormone (plus an additional amino acid). It retains lipolytic effects but lacks the growth-promoting and glucose-regulating effects of full-length growth hormone, according to structural data in the NIH PubChem database.

Is it legal to buy this peptide in the UK?

This compound is supplied as a research chemical for in-vitro laboratory research only. Under MHRA rules, selling or advertising unlicensed medicines to the public is unlawful. UK researchers should ensure it is used solely for legitimate research purposes, as outlined by the UK Government.

Has it ever been approved for human use?

No. It has not been approved by the MHRA or FDA for any indication. In December 2024, the FDA Pharmacy Compounding Advisory Committee (PCAC) rejected its inclusion in the 503A bulk drug list due to immunogenicity risks, impurity profiles, and lack of long-term safety data for injection.

What is the purity of AOD 9604 peptide?

Our AOD 9604 peptide is provided at ≥99% purity, verified by HPLC with third-party testing.

How should it be stored?

Lyophilized powder should be stored at -20°C for long-term stability. Reconstituted material should follow standard laboratory protocols.

Conclusion

AOD 9604 peptide remains a valuable tool compound for studying growth hormone fragment-specific lipolytic signalling. Its structural design—retaining lipolytic effects without activating the growth hormone receptor or elevating IGF-1—provides researchers with a distinct mechanism of action compared with full-length growth hormone, as documented in Frontiers in Endocrinology. For laboratories seeking this peptide in the UK, Cocer Peptides offers high-purity material with complete analytical documentation and batch-specific COA support. Researchers purchasing AOD 9604 peptide should ensure the material is used solely for legitimate in-vitro research purposes.

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