Description

Premium SNAP 8 Peptide – 5mg Research Grade

Product Overview

SNAP 8 peptide is a synthetic octapeptide designed as an elongated analogue of the well-known hexapeptide Argireline (Acetyl Hexapeptide-8). It consists of eight amino acids with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, corresponding to a molecular weight of approximately 1075.16 Da . The INCI name for this compound is Acetyl Octapeptide-3, and it is also known as Acetyl Glutamyl Heptapeptide-3 .

SNAP 8 was developed by Lipotec as an upgraded version of their original Argireline peptide. The addition of two amino acids (alanine and aspartic acid) at the C-terminus was specifically designed to improve molecular stability and enhance binding affinity to the SNARE complex . This structural modification distinguishes it from its parent hexapeptide and forms the basis for its research applications.

For researchers investigating neurocosmetic peptides and neurotransmitter release mechanisms, SNAP 8 peptide provides a well-characterized tool compound. This 5mg research-grade vial is supplied as a lyophilized powder with full analytical documentation.

Important Notice: This product is supplied strictly for laboratory research purposes only. It is not intended for human consumption, clinical application, or cosmetic use.

Product Specifications

Mechanism of Action

SNARE Complex Inhibition

SNAP 8 peptide functions as a competitive inhibitor of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) complex. According to research indexed in the NIH PubMed database, the peptide mimics the N-terminal end of the SNAP-25 protein, which is a crucial component of the SNARE complex . By competing with endogenous SNAP-25 for a position in the SNARE complex, it interferes with vesicle fusion and subsequent neurotransmitter release .

Neurotransmitter Release Modulation

The SNARE complex is essential for the fusion of neurotransmitter-containing vesicles with the presynaptic membrane. Research published in Frontiers in Chemistry describes how SNAP 8 destabilizes the SNARE complex, leading to inefficient vesicle fusion and a subsequent reduction in acetylcholine release . This mechanism is studied for its potential to modulate muscle contraction signaling at the neuromuscular junction.

Structural Advantages Over Hexapeptides

The two additional amino acids in SNAP 8 (compared to Argireline) increase its molecular weight from approximately 890 Da to 1075 Da. According to comparative research indexed in ScienceDirect, this elongation was designed to improve SNARE complex binding and enhance stability against enzymatic degradation . Head-to-head studies suggest SNAP 8 peptide may exhibit approximately 30% higher activity than its hexapeptide parent in neurotransmitter release inhibition assays .

Research Applications

Neurocosmetic Peptide Research

SNAP 8 peptide is extensively studied as a topical neurocosmetic agent. A systematic review published in the Journal of Cosmetic Dermatology evaluated topical botulinum toxin-like peptides and found that SNARE-inhibiting peptides demonstrate statistically significant wrinkle reduction with favorable safety profiles . The review noted that these peptides offer continuous, cumulative benefits through daily use, contrasting with the discrete on/off profile of injectable treatments.

SNARE Complex Studies

Researchers investigating synaptic vesicle trafficking and neurotransmitter release use this octapeptide as a tool to probe SNARE complex dynamics. Its ability to compete with SNAP-25 provides a mechanism for studying the role of this protein in exocytosis. According to structural data available through the NIH PubChem database, the sequence Ac-EEMQRRAD-NH2 corresponds to the N-terminal region of SNAP-25 .

Synergistic Combination Research

SNAP 8 has been studied in combination with other neurocosmetic peptides. Research indexed through BenchChem examined the interaction between SNAP 8 and Leuphasyl (acetyl dipeptide-1 cetyl ester), finding that co-administration produced 47% inhibition of neurotransmitter release compared to 38% for SNAP 8 alone and 7% for Leuphasyl alone . This synergistic interaction is attributed to complementary mechanisms—SNAP 8 competing at the SNARE complex while Leuphasyl acts via enkephalin-like receptor modulation.

Stability and Formulation Research

The structural modifications in SNAP 8 peptide—N-terminal acetylation and C-terminal amidation—protect against exopeptidase degradation. Research published via Nature has examined the stability profile of acetylated peptides in various formulation conditions . These studies provide foundational data for researchers investigating peptide stability and delivery.

Quality and Purity

Each batch of Cocer Peptides SNAP 8 peptide undergoes rigorous quality control:

• ≥97% purity verified by HPLC

• Molecular weight confirmed by mass spectrometry

• Batch/lot number matching the vial label

• Certificate of Analysis (COA) available on request

According to guidance from the Medicines and Healthcare products Regulatory Agency (MHRA), research chemicals must be clearly labeled and not marketed for human use. For researchers sourcing SNAP 8, verifying COA documentation is essential for ensuring product integrity and experimental reproducibility.

Frequently Asked Questions

What is SNAP 8 peptide?

SNAP 8 peptide is a synthetic octapeptide (Acetyl Octapeptide-3) designed as an elongated analogue of Argireline. It functions as a competitive inhibitor of the SNARE complex, mimicking the N-terminal end of the SNAP-25 protein .

How does SNAP 8 differ from Argireline?

SNAP-8 contains eight amino acids compared to Argireline’s six. The two additional residues (alanine and aspartic acid) were added to improve molecular stability and enhance SNARE complex binding affinity . Comparative studies suggest it may exhibit approximately 30% higher activity .

What purity level can I expect?

Our SNAP 8 peptide is provided at ≥97% purity, verified by HPLC with third-party testing.

What research applications is SNAP 8 used for?

SNAP 8 is studied in neurocosmetic peptide research, SNARE complex dynamics, neurotransmitter release modulation, and synergistic peptide combination studies .

How should SNAP 8 be stored?

Store lyophilized powder at -20°C for long-term stability. Reconstituted material should follow standard laboratory protocols.

Is this product suitable for human use?

No. This product is supplied strictly for research purposes only and is not intended for human consumption or cosmetic application.

Conclusion

SNAP-8 peptide represents a valuable research tool for investigating SNARE complex dynamics, neurotransmitter release mechanisms, and neurocosmetic peptide activity. With its high-purity formulation and comprehensive quality documentation, this 5mg vial enables researchers to study the peptide’s competitive inhibition of SNAP-25 and its downstream effects on vesicle fusion. For laboratories seeking it for research applications, this product offers documented sequence data, ≥97% purity, and batch-specific COA support.

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